Antispasmodics are medications that help relax the muscles in the digestive tract. Doctors may prescribe them to help relieve uncomfortable symptoms, such as spasms, that occur with irritable bowel syndrome (IBS).
IBS is a long-term gastrointestinal disorder that affects the digestive system, causing persistent symptoms such as abdominal pain, cramping, and changes in bowel habits. While there is no cure for IBS, various treatments are available to help manage the condition.
Antispasmodics are one of the medications that doctors prescribe to alleviate some of these uncomfortable symptoms.

Antispasmodic medications are a type of muscle relaxer that can help manage IBS symptoms. IBS is one of the
IBS can cause abnormal muscle contractions, known as colon spasms, leading to cramping and pain. Antispasmodics work by relaxing the smooth muscles of the gastrointestinal tract, helping to reduce these contractions and easing the discomfort.
Effectiveness
The effectiveness of these drugs can vary from person to person, and healthcare professionals typically prescribe these medications as short-term treatments for immediate symptom relief rather than long-term solutions for managing IBS.
Read about signs and symptoms of IBS.
There are several types of antispasmodics to help manage IBS. Each type works slightly differently and may be more suitable for certain individuals based on their specific symptoms.
Anticholinergics
Anticholinergics block the action of acetylcholine, a neurotransmitter that causes muscle contractions in the digestive tract. By inhibiting acetylcholine, these drugs
Examples of anticholinergics include:
- dicyclomine (Bentyl)
- hyoscyamine (Levsin)
- hyoscine butylbromide (Buscopan)
These drugs may not be suitable for all individuals due to their side effects, including:
- dry mouth
- blurred vision
- constipation
- dizziness
- difficulty urinating
In some cases, they can also cause an increased heart rate and confusion, particularly in older adults.
Because of the risk of constipation, these antispasmodics are more suitable for irritable bowel syndrome with diarrhea (IBS-D) rather than irritable bowel syndrome with constipation (IBS-C).
Peppermint oil
Peppermint oil is a natural antispasmodic containing menthol that helps block the action of calcium and relax the muscles in the gastrointestinal tract. Research suggests that peppermint oil in enteric-coated capsules
Peppermint oil is available over the counter (OTC). However, individuals should consult with their doctor before taking this supplement.
Common side effects include:
- heartburn
- nausea
- stomach pain
- dry mouth
Read more about treatment options for IBS.
The benefits of taking antispasmodics include effectively relieving IBS-related cramping and abdominal pain, especially for those with muscle spasms. This can significantly improve quality of life by reducing discomfort.
However, they come with risks, such as side effects like dry mouth, constipation, and urinary retention, particularly with prolonged use. These medications may not address all IBS symptoms, like bloating or stool changes, and healthcare professionals do not typically use them as a stand-alone or long-term treatment.
Antispasmodics may not be suitable for people with certain medical conditions or those taking medications that could interact with them. Those who should avoid antispasmodics include individuals with conditions such as:
It is important for individuals to consult their healthcare professional before starting any antispasmodic treatment to ensure the medication is appropriate for their individual health needs, particularly if they are pregnant, nursing, or living with another medical condition.
A comprehensive approach to treatment is often the
- dietary management, such as following a low FODMAP diet
- psychological therapies, such as cognitive behavioral therapy (CBT)
- other medications like laxatives for constipation-predominant IBS
- exercise
Do antispasmodics help IBS?
Yes, antispasmodics can help manage IBS symptoms, particularly abdominal pain and cramping. However, they are typically more effective for individuals whose symptoms are caused by muscle spasms in the intestines. They may not alleviate all IBS symptoms, such as bloating or irregular bowel movements.
Is there an over-the-counter antispasmodic?
In the United States, peppermint oil capsules are the only antispasmodic available OTC. Chamomile tea may also help relieve intestinal or menstrual cramps. Always consult a healthcare professional before using any medication for IBS.
What is the best medication for IBS cramps?
The best medication for IBS cramps depends on the individual and their specific symptoms. For individuals whose main IBS symptom is cramping, research
IBS resources
Visit our dedicated hub for more research-backed information and in-depth resources on irritable bowel syndrome (IBS).
Antispasmodics are medications that can provide much-needed relief from IBS cramping and abdominal discomfort. They work by relaxing the muscles of the gastrointestinal tract.
However, these medications are not suitable for everyone, and they do not address all IBS symptoms.
As part of a broader treatment plan, antispasmodics can play a valuable role in improving quality of life for individuals living with IBS. Always consult with a healthcare professional to determine the best treatment plan depending on individual needs and conditions.