Briumvi (ublituximab-xiiy) is a brand-name injection prescribed for certain types of multiple sclerosis (MS). Briumvi has interactions with certain vaccines and other drugs. Examples include teriflunomide (Aubagio) and azathioprine (Imuran).
Briumvi is prescribed to treat the following conditions in adults:
An interaction occurs when one substance causes another substance to have a different effect than expected.
To learn more about Briumvi’s interactions, keep reading. For additional information, including details about its uses, see this Briumvi overview article.
Before you start treatment with Briumvi, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions. (To learn whether Briumvi interacts with supplements, herbs, or vitamins, see the “Briumvi and other interactions” section.)
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Here’s a list of drugs that can interact with Briumvi. Keep in mind that this table doesn’t include all drugs that may interact with Briumvi. Some of these interactions are described in detail in “Drug interactions in depth.”
Drug class or drug name | Drug examples | Interaction result with Briumvi |
---|---|---|
immunomodulators | • teriflunomide (Aubagio) • dimethyl fumarate (Tecfidera) | can increase the risk of infection |
immunosuppressants | • azathioprine (Imuran) • prednisone • methotrexate (Trexall, others) | can increase the risk of infection |
Sometimes, certain factors or conditions could prevent your doctor from prescribing Briumvi due to the risk of harm. These are known as contraindications. The contraindications of Briumvi include:
Having an active hepatitis B infection
Doctors typically won’t prescribe Briumvi for people with an active hepatitis B infection. This is because Briumvi can worsen your infection. This can lead to serious liver problems, including liver failure or death.
If you have an active hepatitis B infection, talk with your doctor before receiving Briumvi. They’ll likely prescribe a treatment other than Briumvi for your condition.
Having had an allergic reaction to Briumvi or any of its ingredients
If you have had a serious allergic reaction to Briumvi or any of its ingredients, your doctor will likely not prescribe Briumvi. Receiving the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.
Note:Before you start treatment with Briumvi, it’s important to tell your doctor if these contraindications apply to you. They can determine whether to prescribe Briumvi.
There are no known interactions between Briumvi and alcohol. If you have questions about drinking alcohol while receiving Briumvi treatment, talk with your doctor or pharmacist.
Here’s a closer look at certain drug interactions of Briumvi.
Immunomodulators
Immunomodulators are drugs that modify the immune system to treat an illness. Some immunomodulators are used to treat multiple sclerosis (MS).
Interaction result:Receiving Briumvi with an immunomodulator can increase the risk of infection.
Interaction explained:Briumvi and immunomodulators both work by modifying the immune system. (The immune system is responsible for fighting off infections.) Sometimes, taking these drugs together can slow your immune system, making it less effective at fighting off infection. As a result, your risk of infection can increase.
Examples of immunomodulator drugs: Here are some immunomodulators that may interact with Briumvi:
Steps you or your doctor may take:Let your doctor know if you take any immunodulators before you start Briumvi. They can discuss the potential risks and benefits of taking these drugs together. If you and your doctor decide to start Briumvi, report any signs or symptoms of infection to your doctor right away. These may include fever, a cough that won’t go away, chills, or painful urination.
Immunosuppressants
Immunosuppressants are drugs that work by reducing the strength of the immune response.
Interaction result: Receiving Briumvi with an immunosuppressant can increase the risk of infection.
Interaction explained: Briumvi and immunosuppressants both work by slowing the immune response. By doing so, they may prevent your body from fighting off infections as efficiently as usual. Taking these drugs together can further slow your immune system, increasing your risk of infection.
Examples of immunosuppressant drugs: Here are some immunosuppressants that may interact with Briumvi:
- prednisone (Deltasone, others)
- cyclosporine (Neoral, others)
- tacrolimus (Prograf, others)
- azathioprine (Imuran)
- mycophenolate (CellCept, Myfortic)
- adalimumab (Humira)
- rituximab (Rituxan)
Steps you or your doctor may take: Tell your doctor if you take any immunosuppressants before you start Briumvi. They can help determine if it’s safe for you to start Briumvi. If so, they will likely monitor you closely for any signs or symptoms of infection during treatment.
Briumvi may have other interactions, such as with supplements, foods, vaccines, or even lab tests. You’ll find details below. Keep in mind that the following information does not include all other possible interactions with Briumvi.
Briumvi interactions with supplements
It’s possible for drugs to interact with supplements, such as vitamins and herbs.
Briumvi interactions with herbs
There are no specific reports of herbs interacting with Briumvi. However, that doesn’t mean herbal interactions won’t occur or be recognized in the future. Because of this, it’s important to check with your doctor or pharmacist before taking any of these products during Briumvi treatment.
Briumvi interactions with vitamins
There are no specific reports of vitamins interacting with Briumvi. However, that doesn’t mean vitamin interactions won’t occur or be recognized in the future. Because of this, you should talk with your doctor or pharmacist before taking any vitamin product with Briumvi.
Briumvi interactions with food
There were no reports of food interactions with Briumvi. If you’d like to learn more about eating certain foods during treatment with Briumvi, talk with your doctor.
Briumvi interactions with vaccines
Briumvi is known to interact with live vaccines. A live vaccine contains live but weakened pieces of the virus or bacterium it’s meant to defend against. Live vaccines usually won’t cause infection when your immune system is healthy.
But Briumvi works by weakening your immune system. So if you get a live vaccine, your immune system may be unable to fight the virus or bacterium. This may cause you to become sick or develop symptoms of the illness the vaccine is meant to help prevent. Due to this risk, your doctor will likely recommend that you get all necessary live vaccines at least 4 weeks before starting Briumvi. You should not receive any live vaccines while you’re receiving Briumvi.
Examples of live vaccines to avoid during Briumvi treatment include:
- measles, mumps, rubella (MMR)
- chickenpox
- flu vaccine (nasal spray form)
In addition, if you have a child and received Briumvi during pregnancy, your child’s doctor may delay giving them any live vaccines. Tell your child’s doctor if you received Briumvi during pregnancy. They can help determine if it’s safe for your child to receive a live vaccine. (For details about pregnancy and Briumvi, see the “Briumvi and health-related interactions” section.)
Briumvi may also interact with non-live vaccines by making them less effective. For this reason, it’s recommended that you receive any non-live vaccines at least 2 weeks before starting Briumvi. If you need to receive a non-live vaccine during Briumvi treatment, talk with your doctor.
Before starting Briumvi, talk with your doctor or pharmacist about any vaccines you may need.
Briumvi interactions with lab tests
Briumvi is not known to interact with any lab tests. If you have concerns about this medication interacting with lab tests, talk with your doctor.
BRIUMVI INTERACTION WITH CANNABIS OR CBDCannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Briumvi. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Briumvi. The impact of cannabis may affect how well you stick to your Briumvi treatment plan.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions and other factors may increase the risk of interactions with Briumvi. Before you take this drug, be sure to talk with your doctor about your health history. Briumvi may not be the right treatment option if you have certain medical conditions or other factors affecting your health.
Health conditions or factors that might interact with Briumvi include:
- Current infection: Briumvi works by slowing the immune system. Because of this, it can increase your risk of infection. If you have a current infection, Briumvi can worsen your condition. Let your doctor know if you have a current infection. They likely won’t start Briumvi treatment until your infection clears.
- Active or past hepatitis B infection: If you’ve ever had a hepatitis B infection, Briumvi can make the infection active again. This can lead to serious liver problems, including liver failure. Due to this risk, your doctor will likely order tests to check for hepatitis B infection before you start Briumvi. If you have an active hepatitis B infection, your doctor likely won’t prescribe Briumvi.
- Allergic reaction: If you’ve had an allergic reaction to Briumvi or any of its ingredients, your doctor will likely not prescribe Briumvi. Receiving the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.
- Pregnancy: If you’re pregnant or planning to become pregnant, your doctor likely won’t prescribe Briumvi. Briumvi can cause fetal harm. So if you can become pregnant, your doctor will likely recommend that you take effective birth control during treatment and for at least 6 months after your last dose of Briumvi. If you’re pregnant or planning to become pregnant, tell your doctor before starting Briumvi. They can advise you on the right treatment plan.
- Breastfeeding: It is unknown whether it’s safe to receive Briumvi while breastfeeding. If you’re breastfeeding or planning to, talk with your doctor before receiving Briumvi. They can talk with you about treatment options and ways to feed a child who is breastfed.
You can take certain steps to help prevent interactions with Briumvi. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:
- Let them know if you drink alcohol or use cannabis.
- Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
- Create a
medication listTrusted Source , which your doctor and pharmacist can help you fill out.
It’s also important to read the Briumvi label and other
If Briumvi doesn’t come with paperwork, you can ask your doctor to print a copy. If you need help reading or understanding this information, ask your doctor.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.