Kyprolis interactions: Alcohol, medications, and other factors

Kyprolis interactions with other medications

Before you start treatment with Kyprolis, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions. (To learn whether Kyprolis interacts with supplements, herbs, or vitamins, see the “Kyprolis and other interactions” section.)

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Here’s a table of drugs that can interact with Kyprolis. Keep in mind that this table doesn’t include all drugs that may interact with Kyprolis. Some of these interactions are described in detail in “Drug interactions in depth.”

Kyprolis interaction with alcohol

There aren’t any known interactions between Kyprolis and alcohol. However, your doctor may advise you to avoid or limit alcohol consumption during Kyprolis treatment.

This is because drinking alcohol while using the drug may worsen some of Kyprolis side effects. For example, you may experience:

• sleepiness
• headache
• nausea
• vomiting
• dizziness

In addition, consuming large amounts of alcohol can cause liver damage. Kyprolis may also cause liver damage as a side effect. This means that drinking alcohol during Kyprolis treatment may increase the risk of liver problems.

If you consume alcohol during Kyprolis treatment, these side effects may be more likely to occur. If you have questions about drinking alcohol during Kyprolis treatment, talk with your doctor.

Drug interactions in depth

Here’s a closer look at certain drug interactions of Kyprolis.

Combined hormonal birth control

Kyprolis can interact with combined hormonal birth control. This refers to birth control medications that contain both estrogen and progestin. In addition to preventing pregnancy, these medications may be prescribed for other uses, such as acne.

Interaction result: Using Kyprolis and combined hormonal birth control can raise the risk of blood clots as a side effect of Kyprolis and birth control pills.

Interaction explained: Both Kyprolis and combined hormonal birth control can rarely cause blood clots when used on their own. Taking them together may increase your risk of this side effect.

Examples of combined hormonal birth control medications: Here are some combined hormonal birth control medications that may interact with Kyprolis:

• ethinyl estradiol/norelgestromin (Onsura, others)
• ethinyl estradiol/drospirenone (Loryna, others)
• ethinyl estradiol/etonogestrel (NuvaRing, others)
• ethinyl estradiol/levonorgestrel (Ashlyna, others)

Steps you or your doctor may take: If you’re prescribed Kyprolis and can become pregnant, your doctor may suggest using a progestin-only birth control pill, such as drospirenone or norethindrone. Progestin-only pills do not carry the same risk of blood clots as combined hormonal birth control pills. Your doctor may also suggest other forms of birth control, such as condoms. Talk with your doctor to learn more about your options for birth control if you’re prescribed Kyprolis.

Clozapine

Kyprolis can interact with clozapine, which is prescribed to treat treatment-resistant schizophrenia. It’s also used to treat suicidal behavior and ideations in people with schizophrenia.

Interaction result: Using Kyprolis and clozapine can increase the risk of low neutrophil count (neutropenia) as a side effect of Kyprolis and clozapine

Interaction explained: Both Kyprolis and clozapine can cause neutropenia as a side effect when used on their own. Using them together can raise your risk of this side effect.

Steps you or your doctor may take: If you need to use Kyprolis and clozapine together, your doctor may order frequent blood tests to check your neutrophil count throughout treatment.

Kyprolis and other interactions

Kyprolis may have other interactions, such as with supplements, foods, vaccines, or even lab tests. You’ll find details below. Keep in mind that the following information does not include all other possible interactions with Kyprolis.

Kyprolis interactions with supplements

It’s possible for drugs to interact with supplements such as vitamins and herbs.

Kyprolis interactions with herbs

There are no specific reports of herbs interacting with Kyprolis. However, that doesn’t mean herbal interactions won’t occur or be recognized in the future. Because of this, it’s important to check with your doctor or pharmacist before taking any of these products during Kyprolis treatment.

Kyprolis interactions with vitamins

There are no specific reports of vitamins interacting with Kyprolis. However, that doesn’t mean vitamin interactions won’t occur or be recognized in the future. Because of this, you should talk with your doctor or pharmacist before taking any vitamin product with Kyprolis.

Kyprolis interactions with food

There were no reports of food interactions with Kyprolis. If you’d like to learn more about eating certain foods during treatment with Kyprolis, talk with your doctor.

Kyprolis interactions with vaccines

Kyprolis may interact with live vaccines. A live vaccine contains live but weakened pieces of the virus or bacterium it’s meant to defend against. When your immune system is healthy, live vaccines usually won’t cause infection.

But Kyprolis works by weakening your immune system. And, it’s sometimes prescribed with other medications that treat multiple myeloma but can also weaken your immune system. So if you get a live vaccine, your immune system may not be able to fight the virus or bacterium. This may cause you to become sick or develop symptoms of the illness the vaccine is meant to prevent.

Examples of live vaccines to avoid during Kyprolis treatment include:

• cholera (Vaxchora)
• measles, mumps, rubella (MMR)
• chickenpox
• flu vaccine (nasal spray form)

Kyprolis could also affect how well COVID-19 vaccinations work, even though these are not live vaccines. But the potential for Kyprolis to make COVID-19 vaccinations less effective has been reported. As a result, your doctor may recommend receiving additional doses of COVID-19 vaccines, based on recommendationsTrusted Source from the Centers for Disease Control and Prevention (CDC).

Before starting Kyprolis, talk with your doctor or pharmacist about any vaccines you may need.

Kyprolis interactions with lab tests

Kyprolis isn’t known to interact with any lab tests. If you have concerns about this medication interacting with lab tests, talk to your doctor.

KYPROLIS INTERACTION WITH CANNABIS OR CBD

Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Kyprolis. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Kyprolis. The impact of cannabis may affect how well you stick to your Kyprolis treatment plan.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Kyprolis and health-related interactions

Certain medical conditions and other factors may increase the risk of interactions with Kyprolis. Before you receive this drug, be sure to talk with your doctor about your health history. Kyprolis may not be the right treatment option if you have certain medical conditions or other factors affecting your health.

Health conditions or factors that might interact with Kyprolis include:

• Age 75 years or older: People age 75 years and older are at a higher risk of heart failure as a side effect of Kyprolis. Your doctor can determine whether Kyprolis treatment is safe for you. They may monitor your heart health closely if they prescribe the medication.
• Bleeding condition, such as hemophilia: Kyprolis can cause bleeding, which may be severe, as a side effect. If you have a bleeding condition, such as hemophilia, you may be at higher risk of this side effect if you’re treated with Kyprolis. Your doctor can help determine whether Kyprolis treatment is safe for you.
• Breathing or lung condition, such as asthma: Treatment with Kyprolis can cause breathing and lung-related side effects, including shortness of breath and pulmonary hypertension (high blood pressure in the lungs). If you have a breathing or lung condition, such as asthma, you may have a higher risk of these side effects. Kyprolis could also worsen your condition. Talk with your doctor to learn more about the risks and benefits of receiving Kyprolis if you have a breathing or lung condition.
• Heart failure, arrhythmia, or other heart condition: Kyprolis can cause heart-related side effects, including heart attack and heart failure. You may be at a higher risk of heart failure and other heart-related side effects if you have heart failure, arrhythmia, or another heart condition. If your doctor chooses to prescribe Kyprolis to you, they may want to closely monitor your heart health. Talk with your doctor to learn more about the risks and benefits of receiving Kyprolis if you have a heart condition.
• High blood pressure: If you have high blood pressure, it may be worsened if you’re treated with Kyprolis. In rare cases, Kyprolis can cause hypertensive emergency or life threatening hypertensive crisis. You may be at higher risk of these side effects if you have existing high blood pressure. Talk with your doctor to learn more about the risks and benefits of receiving Kyprolis if you have high blood pressure. Your doctor may adjust the dosage of your blood pressure medications if they prescribe Kyprolis to you.
• Kidney condition, such as chronic kidney disease: Kyprolis can cause sudden kidney failure as a side effect in rare cases. You may be at a higher risk of this side effect if you have a kidney condition such as chronic kidney disease.
• Low platelet count (thrombocytopenia): Kyprolis can cause low platelet count (thrombocytopenia) as a side effect. If you have existing thrombocytopenia, your condition can be worsened if you receive Kyprolis. Your doctor can help determine whether Kyprolis treatment is safe for you.
• Liver condition, such as cirrhosis: Kyprolis can cause liver damage and liver failure as side effects. You may be at a higher risk of liver-related side effects from receiving Kyprolis if you have an existing liver condition, such as cirrhosis. Talk with your doctor to learn more about the risks and benefits of Kyprolis treatment if you have cirrhosis or another liver condition.
• Allergic reaction: If you’ve had an allergic reaction to Kyprolis or any of its ingredients, your doctor will likely not prescribe Kyprolis. Receiving the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.
• Breastfeeding: Your doctor will likely advise you to avoid breastfeeding during Kyprolis treatment and for at least 2 weeks after your last dose. If you’re breastfeeding or planning to, talk with your doctor before using Kyprolis. They can talk with you about treatment options and ways to feed a child who’s breastfed.
• Pregnancy: There haven’t been enough clinical trials to determine whether Kyprolis is safe to use while pregnant. Animal studies show that the drug may cause congenital anomalies (commonly known as birth defects) or pregnancy loss. However, it’s important to note that animal studies don’t always indicate what may happen in humans. Still, due to the risk of harm, your doctor will likely suggest using birth control during treatment and at least 6 months following your last dose of Kyprolis. If you’re pregnant or planning to become pregnant, tell your doctor before starting Kyprolis. They can advise you on the right treatment plan for you.

Preventing interactions

You can take certain steps to help prevent interactions with Kyprolis. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:

• Let them know if you drink alcohol or use cannabis.
• Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
• Create a medication listTrusted Source, which your doctor and pharmacist can help you fill out.

It’s also important to read the Kyprolis label and other paperworkTrusted Source that may come with the drug. The label may have colored stickers that mention an interaction. And the paperwork, sometimes called the medication guide or patient package insert, may contain details about interactions.

If Kyprolis doesn’t come with paperwork, you can ask your pharmacist to print a copy. If you need help reading or understanding this information, ask your doctor or pharmacist.

You can also help prevent interactions with Kyprolis by using it exactly as your doctor prescribes.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.