The prescribed dosage for NovoSeven RT may vary depending on a person’s individual treatment plan. Other factors, including your specific diagnosis, body weight, and medical history, may affect your dosage of NovoSeven RT.
NovoSeven RT (coagulation factor VIIa, recombinant) is a prescription drug that’s prescribed for hemophilia and certain other bleeding disorders. The drug comes as a powder in a single-dose vial that’s mixed to make a solution for intravenous (IV) infusion.
NovoSeven RT is used to treat bleeding episodes and help prevent bleeding related to surgery in:
- certain adults and children with hemophilia A or B
- adults with acquired hemophilia
- adults and children with congenital (present from birth) clotting factor VII deficiency (clotting factors are proteins that help the blood clot)
- certain adults and children with Glanzmann thrombasthenia, a condition where the body produces faulty platelets (blood cells that help the blood clot)
This article describes the dosages of NovoSeven RT, as well as its strengths and how to receive it. To learn more about NovoSeven RT, including its uses and side effects, see this in-depth NovoSeven RT article.
Your doctor will likely start you on a low dosage and adjust it over time to reach the right amount for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.
The following information describes dosages that are commonly used or recommended for NovoSeven RT. Be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those mentioned here.
NovoSeven RT forms
NovoSeven RT is available as a powder in a single-dose vial that’s mixed to make a solution for IV infusion.
NovoSeven RT strengths
NovoSeven RT comes in four strengths:
- 1 milligram (mg), which is 1,000 micrograms (mcg)
- 2 mg (2,000 mcg)
- 5 mg (5,000 mcg)
- 8 mg (8,000 mcg)
NovoSeven RT is approved to treat bleeding episodes and help prevent bleeding related to surgery in certain people.
The prescribed NovoSeven RT dosage may vary depending on the condition it’s being used to treat. Always follow your prescribing doctor’s instructions. Notify them if you experience any side effects that may prevent you from taking your medication.
Dosage for treating bleeding episodes
NovoSeven RT is prescribed to treat bleeding episodes in certain situations. Dosages are based on the condition causing the bleeding episode, as well as body weight based on kilograms (kg). For reference, 1 kg is about 2.2. pounds (lb).
See the table below for details of recommended dosages of NovoSeven RT for treating bleeding episodes.
| Recommended dosage | |
|---|---|
| for adults with hemophilia A or B with inhibitors | • 90 mcg/kg every 2 hours until the bleeding stops • if the bleed was severe, your doctor may recommend further doses of 90 mcg/kg every 3 to 6 hours for a period of time |
| for adults with acquired hemophilia | 70 to 90 mcg/kg every 2 to 3 hours until the bleeding stops |
| for adults with congenital factor VII deficiency | 15 to 30 mcg/kg every 4 to 6 hours until the bleeding stops |
| for adults with Glanzmann thrombasthenia | 90 mcg/kg every 2 to 6 hours until the bleeding stops |
Talk with your doctor if you have questions about your dosage of NovoSeven RT.
Dosage for preventing bleeding related to surgery
NovoSeven RT is used to help prevent bleeding related to surgery in certain situations.
Dosing recommendations are typically based on whether you’re having a minor or a major surgery. Your doctor will determine if the type of surgery you’re having is minor or major and your bleeding risk for that surgery. This will help them calculate your dose. If you have questions about this, you can follow up with your doctor.
See the table below for details of recommended dosages of NovoSeven RT for preventing bleeding related to surgery.
| Recommended dosage | |
| for adults with hemophilia A or B with inhibitors, minor surgery | • 90 mcg/kg given right before surgery, then 90 mcg/kg every 2 hours during surgery • after surgery, give 90 mcg/kg every 2 hours for 48 hours, then 90 mcg/kg every 2 to 6 hours until healing occurs |
| for adults with hemophilia A or B with inhibitors, major surgery | • 90 mcg/kg given right before surgery, then 90 mcg/kg every 2 hours during surgery • after surgery, give 90 mcg/kg every 2 hours for 5 days, then 90 mcg/kg every 4 hours until healing occurs |
| for adults with acquired hemophilia | 70 to 90 mcg/kg given right before surgery, then 70 to 90 mcg/kg every 2 to 3 hours during surgery and until any bleeding stops |
| For adults with congenital factor VII deficiency | 15 to 30 mcg/kg given right before surgery, then 15 to 30 mcg/kg every 4 to 6 hours during surgery and until any bleeding stops |
| for adults with Glanzmann thrombasthenia | • 90 mcg/kg given right before surgery, then 90 mcg/kg every 2 hours during the surgery • after surgery, give 90 mcg/kg every 2 to 6 hours for a period of time to prevent bleeding |
Talk with your doctor if you have questions about your dosage of NovoSeven RT.
NovoSeven RT is FDA approved to treat bleeding episodes and help prevent bleeding related to surgery in children with:
- hemophilia A or B with inhibitors
- congenital (present from birth) factor VII deficiency
- Glanzmann thrombasthenia, when platelet transfusions don’t work
The dosage for children is based on body weight and is the same as the dosage for adults. See the “Dosage of NovoSeven RT by condition” section for details.
For more information about NovoSeven RT’s dosage for children, talk with your child’s doctor or a pharmacist.
NovoSeven RT is administered by a doctor, nurse, or other healthcare professional. You’ll typically receive NovoSeven RT in a clinical setting, such as a hospital.
NovoSeven RT is available as a vial of powder, which comes with a prefilled syringe or a vial containing a solution of histidine. This is called a diluent. It’s mixed with the powder to make a solution that’s given by IV infusion.
Infusions are typically given over 2 to 5 minutes. However, doctors may sometimes administer the drug as a continuous infusion if it’s being used to help prevent bleeding with major surgeries. (A continuous infusion is an injection into a vein continuously over a longer period of time.)
In some cases, a healthcare professional may teach you how to prepare and administer NovoSeven RT infusions. In these cases, you or your caregiver may be able to give the infusion for yourself or your child to treat bleeding episodes at home.
Length of treatment
NovoSeven RT is typically prescribed for a limited time. Your doctor will determine your individual treatment plan, including how long you will receive NovoSeven RT.
Do not administer more NovoSeven RT than your doctor prescribes, as this can lead to harmful effects.
What to do in case you take too much NovoSeven RT
Call your doctor right away if you think you’ve taken too much NovoSeven RT. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.